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Furthermore, it is noteworthy that astrocytes, in concert with the choroid plexus, nasal lymphatic vessels, and CSF, are recognised as integral constituents of the glymphatic system thereby, the glymphatic system may provide a conduit for viral infiltration into the brain [18]

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Other studies on breast cancer, prostate cancer, and squamous cell carcinoma of the oral cavity have reported similar findings, reinforcing this conclusion [31,32,33,34]

however, they are not user-friendly, and, when compared to implantable devices the BBB opening procedure can be time-consuming